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Prednisone Side Effects: Everything You Need to Know. By Amber J. Tresca. Updated on May 30, 2023. Medically reviewed by Jay N. Yepuri, MD. …By Mayo Clinic Staff. Corticosteroid medicines include cortisone, hydrocortisone and prednisone. They are useful in treating rashes, inflammatory bowel …According to drugs.com, it is not advisable to drink alcohol while taking Prednisone, one of the more commonly prescribed oral steroids. Many drugs can interact with Prednisone, in...Side Effects. See also Warning section. Constipation, nausea, headache, diarrhea, vomiting, stomach upset, gas, tremor, dizziness, drowsiness, or trouble sleeping may occur. If any of these ...Dizziness, lightheadedness, tiredness, or headache may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects last or get worse, tell your doctor or ...Prednisone is a corticosteroid medicine used to decrease inflammation and keep your immune system in check, if it is overactive. 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